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16 Smooth Muscle Intermediate filaments Adhesive Nucleus Actin-myosin filaments Thickening zones Smooth ER (Ca2 stores) plaques Myocyte 7 106moll Myosin II Caldesmon (CDM) Ca2 CM 2 Calmodulin binding 4 CDM Ca2 CM Release of actin Actin-tropomyosin Low muscle tone 8 P Phosphatase ATP P ADP Phosphorylation of myosin II or 5 PK-C ATP RLC [Ca2]i Ca2 Ca2 1 Ca2 Ca2 [Ca2]i 106moll ATP 9 P PK-C MLCK Ca2 CM 3 Contraction: Increased tone P Filaments slide 71 Despopoulos, Color Atlas of Physiology © 2003 Thieme All rights reserved.
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