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As mentioned earlier, there are several other disorders of purine and pyrimidine metabolism, some of them with hyperuricemia, that present with a neurologic syndrome like that of Lesch-Nyhan. Groups were brought into mathematics in the early nineteenth century by the radical young French student Evariste Galois as a tool to help solve one of the outstanding problems of his day: to find a formula for solving polynomial equations of order five- quintics-and higher.

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